Dà bicyclo isomeric [4.1.0] analogues heptane den inhibitor glycosidase galacto-validamine, (1R *, 2S, 3S, 4S, 5S, 6S *) -5-amino-1- (hydroxymethyl) bicyclo [4.1.0] heptane -2,3,4-triol, air an co-chur ann an 13 ceumannan bho 2,3,4,6-tetra-O-benzyl-D-galactose.Chaidh gnìomhan bacaidh an dà amines cuibhrichte gu co-rèiteach, agus na h-acetamides co-fhreagarrach aca, a thomhas an aghaidh enzyman malairteach alpha-galactosidase bho bean cofaidh agus E. coli.Chaidh gnìomhachd an enzyme GH27 teaghlach glycosyl hydrolase (bean cofaidh) a bhacadh gu farpaiseach leis an 1R, 6S-amine (7), eadar-obrachadh ceangail a bha air a chomharrachadh le luach K (i) de 0.541 microM.Sheall an GH36 E. coli alpha-galactosidase eadar-obrachadh ceangail mòran nas laige leis an 1R,6S-amine (IC(50) = 80 microM).Bha an diastereomeric 1S,6R-amine (9) ceangailte gu lag ris an dà chuid galactosidases, (bean cofaidh, IC(50) = 286 microM) agus (E. coli, IC(50) = 2.46 mM).
